EFFECTS OF POLYACTIN A ON THE HEMOLYSIN ANTIBODY PRODUCTION IN MICE
- VernacularTitle:多抗甲素对小鼠抗体生成的作用
- Author:
Tianran WANG
;
Zhixun XIE
- Publication Type:Journal Article
- Keywords:
Polyactin A;
Immunopharmacology;
Mice;
SRBC Hemolysin antibody;
Spleen;
Kinetics
- From:
Chinese Pharmacological Bulletin
1987;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
In this report, the immunopharmacological effects of Polyactin A ( PAA ) were presented. When the SRBC immunized mice were administered daily 2. 5~40mg/kg ( ip ) of PAA for 3 or 5 days, the serum level of hemolysin, the antibody production in spleen and the number of nucleated cells of spleen were enhanced significantly; and the efficacy-dose dependency was evident in these experiments。 In spite of these effects, PAA didn't affect the kinetics of circulating antibody level.In other experiments, it was found that the efficiency was more potent when PAA was given before or simultaneously with SRBC immunization than given after.
