Effects of Periconceptional Folate Intake and Methylenetetrahydrofolate Reduetase Gene C667T Polymorphism of Pregnant Women on Congenital Heart Diseases in Offspring
- VernacularTitle:孕母叶酸摄入与MTHFR基因C677T多态性对子代先天性心脏病发病风险研究
- Author:
Ting PENG
;
Xiaotian LI
;
Li WANG
- Publication Type:Journal Article
- Keywords:
Congenital heart disease;
MTHFR gene;
C677T mutation;
Risk factor;
Folate;
Periconceptional mother
- From:
Journal of Environment and Health
2007;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the environmental risk factors,periconceptional folate intake and methylenetetrahydrofolate reduetase(MTHFR) gene C667T polymorphism of pregnant women on congenital heart diseases(CHD) in offspring.Methods Retrospective case-control study was carried out to investigate periconceptional folate supplementation and environmental factors in 98 parents with CHD offsprings and 101 parents with normal offsprings.The mothers'MTHFR gene C667T mutation was also identified.The possible risk factors were analyzed by simple and multiple factors Logistic regression methods.Results Six factors were related to the occurrence of CHD in the offspring:education of gestation mother,no prenatal examination,under depressed or nervous condition during pregnancy and maternal exposures to harmful substance;periconceptional folate and compound vitamin supplementation were protection factors.There were significant difference between case and control group in folate supplement(P
