Role of NF-?B in the mechanism of liver injury following intestinal perforations due to abdominal firearm wound in pigs
- VernacularTitle:腹部火器伤肠管穿透后NF-?B在肝损伤发病机制中的作用
- Author:
Zexin LI
;
Xiao WANG
;
Huichao XUE
;
Jiangwei LIU
;
Yongjiu ZHANG
- Publication Type:Journal Article
- Keywords:
Nuclear factor- ?B?Tumor necrosis factor - ??Abdominal injury?Firearm wound? Liver injury
- From:
Chinese Journal of Current Advances in General Surgery
2009;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the role of NF- ?B in the mechanism of liver injury following intestinal perforations due to abdominal firearm wound. Methods:A total of 42 Chang-Bai piglets were assigned randomly into 7 groups: control group and wounded 1, 2, 4, 8, 12, 24 hours group.The model of intestinal perforations due to abdominal firearm wound was established in wounded groups. Hepatic NF-?B and TNF-? content was measured with immunohistochemical staining and image analysis in all groups. Hepatocyte apoptosis indexes and serum ALT levels were also determined at the same time. The alterations of hepatic tissue were observed under light microscope. Results: Levels of hepatic NF-?B activity in wounded groups were significantly elevated compared with control group, and two peaks appeared in 1 h group and 8 h group, respectively (P
