Advancement in Intestinal Barrier Dysfunction of Severe Acute Pancreatitis
- VernacularTitle:重症急性胰腺炎肠屏障功能障碍的研究进展
- Author:
Yongpeng DIAO
;
Hong CHEN
;
Fei LI
- Publication Type:Journal Article
- Keywords:
Severe acute pancreatitis;
Intestinal barrier dysfunction;
Bacterial translocation;
Endotoxin translocation
- From:
Chinese Journal of Bases and Clinics in General Surgery
2008;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To summarize the recent progress in pathogenetic,diagnostic and therapeutic researches on the intestinal barrier dysfunction(IBD) of severe acute pancreatitis(SAP).Methods The advancement of IBD in SAP,which was published recently at home and abroad,was collected and reviewed.Results The pathogenesis of IBD in patients with SAP was complex.Ischemia-reperfusion injury,endotoxin,inflammatory mediators and gastrointestinal hormone played an important role in the process of IBD.There were many ways to detect IBD,and the ratio of lactulose and mannitol,plasma diamine oxidase were relatively ideal markers.Medical therapies,such as treatment of SAP and maintaining the perfusion of intestines,were essential to cure IBD.On this basis,the propulsives,nutritional support and traditional Chinese drugs should be administered reasonably.Conclusions IBD is a sophisticated process of pathophysiology.In recent years,abundant of animal experiments and clinical researches have provided new clue for prevention and cure of IBD,but further researches are still needed on the mechanism of the cells and molecules implicated.
