PRECANCEROUS LESIONS AND HISTOGENESIS OF RAT HEPA-TOCELLULAR CARCINOMA INDUCED BY AFLATOXIN B_1
- VernacularTitle:黄曲霉毒素B_1诱发大鼠肝癌的癌前病变与肝癌的组织发生学
- Author:
Wenzhao TAO
- Publication Type:Journal Article
- Keywords:
aflatoxin B1;
precancerous lesions;
hepatocellular carcinoma;
histogenesisis;
rats
- From:
Academic Journal of Second Military Medical University
1982;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
The results of the rat hepatocellular carcinoma (HCC) induced by purified afla-toxin B1 (AFB1)were as follows. (1) The precancerous lesions included hepatocytic dysplasia (58.6%), eosinocytic proliferative foci (51.61%) with most positive results by indirect immunoperoxidase-labelling technique for ?-fetoprotein (IIP-AFP), and basophilic proliferative foci with all negative results by IIP-AFP. (2) In 11 cases of HCC, there were 7 with multicentric origin and 4 with single origin, and 9 of 11 cases were in gradeⅠ differentiation and 2 in grade Ⅱ differentiation. (3) In 11 cases of HCC, 7 were of large cell type of HCC and 4 small cell type of HCC. (4) The specimens of 6 cases of HCC were examined by electronic microscopy, and it was found that the differentiation in the large cell type of HCC was better than that in the small cell type of HCC. The authors assume that there may exist multicentric and single origins in the histogenesis of HCC, and AFB1 is likely to be a carcinogen of human non-cirrhotic HCC.
