The study on RUNX1 and its target gene SLC9A3R1 in bone marrow CD34~+ cells from patients with psoriasis
- VernacularTitle:银屑病患者骨髓CD34~+细胞RUNX1及其靶基因SLC9A3R1的研究
- Author:
Junqin LI
;
Xinhua LI
;
Ruixia HOU
;
Kaiming ZHANG
- Publication Type:Journal Article
- Keywords:
Psoriasis;
Bone marrow;
CD34+ cells;
RUNX1;
SLC9A3R1
- From:
Chinese Journal of Immunology
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To reveal the relation between RUNX1 and hematopoietic cells by examination of the expression of RUNX1 and its target gene SLC9A3R1 in bone marrow CD34+ cells from patients with psoriasis,as well as the RUNX1 linkage locus between SLC9A3R1 and NAT9.Methods:Bone marrow CD34+ cells were isolated from psoriatic patients and normal persons by immunomagnetic cell selection.Expression of mRNA for RUNX1 and SLC9A3R1 were analyzed using reverse transcriptase-polymerase chain reaction(RT-PCR),the RUNX1 linkage locus between SLC9A3R1 and NAT9 was detected.Results:The positive frequency of RUNX1 in bone marrow CD34+ cells from patients with psoriasis was lower than in normal controls(P
