BRAIN MONOAMINE CONTENTS AND ANTIULCEROGENIC EFFECTS OF FURAZOLIDONE IN RATS
- VernacularTitle:脑内单胺类递质含量和呋喃唑酮的抗胃溃疡作用
- Author:
Longguang CAO
- Publication Type:Journal Article
- Keywords:
gastric ulcer;
furazolidone;
monoamines;
disease models,animal;
rats
- From:
Academic Journal of Second Military Medical University
1982;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Our previous work showed that, in the rats with reserpine-induced gastric ulcer, brain monoamines (NE, DA and 5-HT) were exhausted and furazolidone completely prevented such a gastric ulcer.The present study was carried out to observe brain monoamine contents and antiulcerogenic effects of furazolidone in other gastric ulcer modtls of rats.It was found that in the rats with gastric ulcer induced by restraint in water (21℃ for 18[h), brain NE content was significantly decreased.Furazolidone partially prevented this gastric ulcer and increased brain monoamines in these animals.In the rats with gastric ulcer induced by indomethacin or pyloric ligature, brain monoamines were unchanged and no effects of furazolidone were observed.These results suggest that the inhibitory effect of furazolidone on brain monoamine oxidase may be the mechanism of its antiulcerogenic action.
