Effects of Dimethylformamide on Spermatozoa Quality and Sex Hormone Levels in Male Mice
- VernacularTitle:二甲基甲酰胺对雄性小鼠精子质量及其性激素的影响
- Author:
Lu HUANG
;
Xujian HOU
;
Yunhe ZHENG
- Publication Type:Journal Article
- Keywords:
Dimethylformamide;
Sperm;
Sex hormones
- From:
Journal of Environment and Health
2007;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of DMF on the quality of spermatozoa and sex hormone levels in male mice,and the possible mechanism. Methods Forty male KM mice were randomly divided into four groups and then treated with DMF dissolved in distilled water by gavage (10 ml/kg) at the doses of 0,0.5,1 and 2 g/kg,once a day for 30 consecutive days. The mice were weighted and then sacrificed on day 31. The epididymises were collected for determination of sperm motility,sperm counting and determination of abnormal sperm rate. The T,LH,and FSH levels in serum were determined. Results Compared with the control group,mice in all treated groups showed significant decrease in body weight (P
