Expression of chemokine receptor CCR7 and CXCR4 in human colorectal carcinoma and its significance
- VernacularTitle:趋化因子受体CCR7及CXCR4在结肠癌组织中的表达及意义
- Author:
Wenying JIANG
;
Jianliang ZHANG
;
Zhipeng JI
;
Qinye FU
;
Yong ZHOU
- Publication Type:Journal Article
- Keywords:
Receptor,chemokine?Colonic neoplasms?Lymphatic metastasis
- From:
Chinese Journal of Current Advances in General Surgery
2009;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the expression of chemokine receptor CCR7 and CXCR4 in human colorectal carcinoma and its significance,so as to assess their expression with the metastasis and prognosis of colorectal carcinoma. Methods:Immunohistochemistry was used to detect the expression of chemokine receptor CCR7 and CXCR4 in 110 patients with colon cancer.The relationship between the CCR7 and CXCR4 expression and the clinic pathological characters was statistically analyzed. Results:CCR7 and CXCR4 expression were positively expressed in 59.1% and 45.5%of the patients. The high expression rate of CCR7 and CXCR4 in lymph node metastasis positive cases was 81. 5% and 60.0% respectively,but the without lymph node metastasis positive cases were 26.7% and 24.4% respectively. The positive expression was significantely higher in the patients with lymph node metastasis than those non-lymph node metastasis(P
