Expressions of DEC1 and STAT3 in gastric cancer tissues
- VernacularTitle:DEC1和STAT3在胃癌组织中的表达及意义
- Author:
Binbin LI
;
Yan ZHENG
;
Yanfei JIA
;
Min WANG
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms?BHLHB2 protein?STAT3 transcription factor
- From:
Chinese Journal of Current Advances in General Surgery
2009;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression and relationship of differentiated embryo-chondrocyte expressed gene1(DEC1) and the signal tranducers and activator of transcription3 (STAT3) in gastric cancer tissues,and the significance of the two genes in gastric carcinogenesis. Methods:Immunohistochemistry method of SP was adopted to discover the expression of DEC1 and STAT3 in 59 gastric cancer tissues,19 normal tissues distant from tumor were regarded as control. Results:The positive expression rate of DEC1 in gastric cancer tissues was 71.2%(42/59),which was significantly higher than that in normal para-cancer tissues(26.3%)(P0.05). STAT3 expression was associated with TNM staging,invasion depth,lymph node involvement and tumor grade (P0.05). Conclusions:DEC1 expression was higher in gastric cancer tissues than that in normal para-cancer tissues distant from tumor,and was correlated with STAT3 in gastric cancer. DEC1 and STAT3 are both transcription factors,therefore the co-activation of DEC1 and STAT3 may play an important role in the carcinogenesis and development of gastric cancer.
