EFFECTS OF GLUCOCORTICOID ON ELECTRICAL ACTIVITIES OF HIPPOCAMPAL NEURONS OF RATS IN VITRO
- VernacularTitle:糖皮质激素对大鼠离体海马神经元电活动的影响
- Author:
Shaoying HUA
- Publication Type:Journal Article
- Keywords:
glucocorticoid;
hippocampal slice;
membrane potential;
cell input resistance;
rats
- From:
Academic Journal of Second Military Medical University
1981;0(04):-
- CountryChina
- Language:Chinese
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Abstract:
IntraccUular recording of the rat hippocampal slices was established and used to analyse the effects of glucocorticoid on resting membrane potential as well as input resistance of the cells in CA1 and CA2 of hippocampal slices.The results indicate that the steroid hyperpolarized some of the hippocampal neurons with a tendency of increasing the cells'input resistance within 1-2 min, suggesting that glucocorticoid can influence the function of central neurons in a non-genomic pattern, and the underlying mechanism involves the change of resting membrane potential.
