Influence of the fetal microchemirism in the thyroid glands on the Graves' disease animal model
- VernacularTitle:胎儿微嵌合体对Graves病动物模型制备的影响
- Author:
Dan PU
;
Hui GUO
;
Aiqun MA
;
Binying SHI
- Publication Type:Journal Article
- Keywords:
Graves' disease;
microchimerism;
animal model
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
1981;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the influence of the fetal microchemirism in the thyroid tissue on the Graves' disease(GD) animal model.Methods Mice in experimental group were injected with Ad-TSH289(5?108IU) to construct the GD animal model,and when the immunization was over,the experimental group was randomly divided into three parts again: two groups were mated with male mice until two weeks of pregnancy or two weeks post-partum while the other group was simple immunized with Ad-TSH289 only.SRY was tested by real-time PCR.Thyroid tissue was stained with HE for pathological examination.Results Histological examination of the thyroid gland revealed that 61.8% of simple immunized mice had goiter,the success rate of GD animal model was 38.5% in pregnancy group,but 76.9% in postpartum groups(P
