Effect of p38MAPK Pathway on TNF-? mRNA and ICAM1 mRNA Expressions of Isolated Rabbit Liver Tissue During Early Stage of Cold Preservation and Reperfusion Period
- VernacularTitle:p38MAPK信号转导途径对缺血再灌注早期离体肝脏细胞因子表达的影响
- Author:
Yu WANG
;
Lijun TANG
;
Ruiwu DAI
;
Yong YAN
- Publication Type:Journal Article
- Keywords:
Liver;
Ischemia-reperfusion;
Injury;
Mitogen activated protein kinase;
Tumor necrosis factor;
Intercellular adhesion molecule;
Inhibitor
- From:
Chinese Journal of Bases and Clinics in General Surgery
2003;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
0.05). At time points of end of cold preservation, 10, 30 and 60 min of reperfusion, the activity of p38MAPK in control group was significantly higher than that at the time points of before resection and 120 min of reperfusion (P0.05). The expressions of TNF-? mRNA and ICAM1 mRNA at the time points of before resection, end of cold preservation, and 10 and 30 min of reperfusion were significantly lower than those in 60 and 120 min of reperfusion in both two groups (P
