Observation of Curative Effect of Gastric Bypass Operation on Non-Obese Type 2 Diabetes and Change of Glucagon-Like Peptide-1
- VernacularTitle:胃转流术对非肥胖型2型糖尿病的疗效观察及其对胰高血糖素样肽-1的影响
- Author:
Zhizhou DENG
;
Lie WANG
;
Yiyang LIN
;
Yu WANG
- Publication Type:Journal Article
- Keywords:
Gastric bypass operation;
Type 2 diabetes;
Non-obese;
Glucagon-like peptide-1;
Insulin;
Plasma glucose
- From:
Chinese Journal of Bases and Clinics in General Surgery
2003;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the curative effect on non-obese type 2 diabetes and the effect on change of glucagon-like peptide-1 (GLP-1) of gastric bypass operation. Methods Thirty-two cases of gastric ulcer with non-obese type 2 diabetes were suffered gastric bypass operation. Plasma glucose concentrations, insulin and GLP-1 were measured respectively in fasting and postprandial conditions before operation and in week 1, 2, 3 and month 1, 3, 6 after gastric bypass operation, and the body mass index (BMI), homeostasis model assessment ? cell function index (HBCI) and glycosylated hemoglobin (HbA1c, the index was detected only before operation and in month 3, 6 after operation) were also measured. The turnover of the diabetes condition in the 6th month after surgery was observed. Results Compared with the levels before operation, the fasting and postprandial plasma glucose levels were descending (P0.05). The diabetes control rate was 78.1%(25/32) overall six months after operation. Level of GLP-1 was negatively correlated with level of plasma glucose (P
