Therapeutical effects of doxycycline on rabbit immobilized osteoarthritis
- VernacularTitle:强力霉素对兔制动骨关节炎模型的治疗作用
- Author:
Shangpu ZHANG
;
Chenhui SHI
;
Jin ZHAO
- Publication Type:Journal Article
- Keywords:
osteoarthritis;
doxycycline;
urokinase-type plasminogen activator;
matrix metalloproteinase
- From:
Orthopedic Journal of China
2006;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
[Objective]To investigate the effects of doxycycline on rabbit immobilized osteoarthritis and their mechanism.[Method]Twenty-four rabbits were randomly divided into normal,model,control and treatment groups,with 6 rabbits in each group.All of the animals were immobilized the lower left limbs with plaster bandage for 4 weeks except normal group.Doxycycline was orally given to treatment group.Cartilage degeneration of the medial condyle of femur was observed at 4 weeks and the levels of collagen-Ⅱ,uPA and MMP-13 were tested.[Result]Cartilage degeneration in treatment group was significantly slighter than those in model and control groups.Data of collagen-Ⅱ,uPA and MMP-13 between model and control groups had no significant difference,but a noticeable statistical difference among other groups.The uPA activity was positively correlated with MMP-13.[Conclusion]Doxycycline inhibits the degeneration process of cartilage and improves the structure.The effects may be related to the inhibition of uPA and MMP-13.
