Expression of c-erbB-2 and ki67 proteins in simple intestinal metaplasia,atypical intestinal metaplasia and gastric adenocarcinoma
- VernacularTitle:c-erbB-2和ki67在胃黏膜肠上皮化生及胃癌组织中的表达
- Author:
Jingyan YANG
;
Jianping ZHANG
;
Fengjun LIU
;
Zhumei ZHAO
;
Yao ZHENG
;
Wenjun LIU
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms? Intestinal neoplasia ?C-erbB-2 protein? ki67 protein
- From:Chinese Journal of Current Advances in General Surgery
2004;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the expressions of c-erbB-2 and ki67 proteins in simple intestinal metaplasia(SIM),atypical intestinal metaplasia(AIM) and gastric adenocarcinoma,and the relationships among them.Methods:The immunohistochemical EnVision method was used to determine the expressions of c-erbB-2 and ki67 in 27 cases of SIM,26 cases of AIM and 37 cases of gastric adenocarcinoma.Results:The positive rates of c-erbB-2 and ki67 in gastric adenocarcinoma were significantly higher than that in SIM(P0.05).Conclusion:The high expression of c-erbB-2 and ki67 in AIM and gastric adenocarcinoma suggested that AIM may play an important role in gastric adenocarcinoma.The AIM is one kind of precancerosis of gastric adenocarcinoma.
