Evaluation on case reports of inadvertent intrathecal vincristine administration
- VernacularTitle:误行鞘内注射长春新碱事件病例报告的系统评价
- Author:
Huihui LIU
;
Chang XU
;
Huilai MA
;
Guang ZENG
- Publication Type:Journal Article
- Keywords:
Vincristine;
Injections,spinal;
System evaluation
- From:
Chinese Journal of Disease Control & Prevention
2009;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the reasons for intrathecal administration of vincristine,the characteristics of patients with nerve damage,and the effective rescue measures and outcome prognosis.Methods Electronic literature databases,English and Chinese Paper Documents databases,and Network Engine were searched for Case Reports of inadvertent intrathecal injection of vincristine.SPSS 15.0 was used for statistical analysis.Results Analysis of 32 cases report showed that the intrathecal injection of vincristine in patients had adverse outcome.Of these cases 25 led to death,and survival of cases was associated with lower limb paralysis or quadriplegia.Fatalities appeared due to a progressively ascending myeloencephalopathy.Early recognition and immediate treatment with CSF drainage appeared to be the only intervention that had improved patients' survival.The survival curves of different surgical treatments,whether or not to use folic acid treatment,whether or not to use glutamate treatment,whether or not to use pyridoxinetreatment,was a significant difference.Conclusions Timely ventriculo-lumbar washout,using folic acid treatment and glutamate treatment appear critical.It is difficult to obtain satisfactory clinical outcome,so the key lies in the implementation of effective preventive measures.
