AN EXPERIMENTAL STUDY ON THE INNER EAR IMPAIRMENT INDUCED BY KANAMYCIN IN IRON -DEFICI ENT YOUNG RATS
- VernacularTitle:卡那霉素对缺铁性幼龄大鼠内耳损害的实验研究
- Author:
Fanlu CHI
- Publication Type:Journal Article
- Keywords:
kanamycin;
ototoxicitv;
iron deficiency;
hearing loss;
inner ear
- From:
Academic Journal of Second Military Medical University
1985;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
In this study, we observed the changes of function and structure of inner ear in iron-deficient growing rats receiving kanamycin intramuscularly using auditory elec-trophysiological, histopathological, enzyme histochemical and scanning electron microscopic techniques.The results showed that in an equal dose of kanamycin, the incidence of hearing loss was much higher and the severity of hearing damage, more scr- ious in iron-deficient rats than those in normal rats.The succino-dehydrogenase activity of inner ear was more obviously inhibited by interaction of kanamycin and iron deficiency than that by one of them.Iron deficiency might increase the sensitivity of inner ear to kanamycin.The results indicate that iron deficiency may be one of the reasons for high incidence of drug deafness in children, and it should be cautious when using such drugs in iron-deficient anemia children.
