Involvement of Free Radicals in Postischemic Damage of the Gerbil Brains
- VernacularTitle:沙土鼠脑缺血后的自由基损害作用
- Author:
Yingqi ZHOU
- Publication Type:Journal Article
- Keywords:
cerebral ischemia;
Na~+, K~+-ATPase;
superoxide-dismutase;
lipid peroxides;
allopurinol
- From:
Academic Journal of Second Military Medical University
1982;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
The effect of bilateral carotid occlusion for 60 min and reperfusion for 30 min on levels of water and lipid peroxides (LPO) and activities of Na+, K+ -ATPase and superoxide dismutase (SOD) in the forebrain was studied in gerbils (Meriones unguiculatus). Luring occlusion, increased water content and decreased activities of Na+, K+-ATPase and SOD were observed. After reperfusion, the activities of Na+, K+ -ATPase and SOD continued decreasing, but LPO elevated apparently. These results support a hypothesis that the free radicals may contribute to the damage of ischemic brain tissue. Pretreatment of gerbils with allopurinol offered protection to cerebral Na+, K+ -ATPase and SOD subsequent to secondary ischemia.
