Pulmonary Surfactant System Defects and Their Causes: An Investigation in Acute Canine Pancreatitis
- VernacularTitle:急性胰腺炎狗肺表面活性物质系统的损伤及其机理
- Author:
Ziqiang DING
- Publication Type:Journal Article
- Keywords:
acute pancreatitis;
pulmonary surfactant;
chloroquine
- From:
Academic Journal of Second Military Medical University
1982;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Twenty mongrel dogs were used and randomly divided into three groups: sham-operated controls, dogs with induced acute hemorrhagic pancreatitis (AHP) and those treated with chloroquine (Ch1) before AHP was induced (AHP+Ch1). AHP was induced by injcction of auto-bile 1 ml/kg into the main pancreatic duct. The results revealed that in AHP, bronchoalveolar lavage fluid (BALF) cell count increased significantly, particularly the alveolar typeⅡ cells and polymorphonuclear leukocytes (PMNs). BALF and cell total phospholipid content (TPL) decreased significantly, of which lysophos-phatidylcholine (LPC) increased, phosphatidylcholine (PC) and dipalmitoly phosphatidylcholine (DPPC) decreased. Lung homogenate showed no change in TPL, but had increased percentage of LPC and decreased percentage of PC and DPPC. Surface activity of BALF and its extracted phospholipid decreased significantly in AHP. Pretreatment with chloroquine can obviously prevent some of the changes in BALF cell types and in percent composition of phospholipid, but had no impact on PS activity. It is suggested that PLA2 participates in developments of pulmonary surfactant system defects and chloroquine has potential value in the treatment of acute lung injury that follows acute pancreatits.
