Effect of Perinatal Sulphamethazine Exposure on Neurotrophs Expression in Hippocampus of Offspring in Rats
- VernacularTitle:围生期接触磺胺二甲嘧啶对子代大鼠海马神经营养因子家族表达的影响
- Author:
Jintao WANG
;
Ding SUN
;
Hao ZHANG
- Publication Type:Journal Article
- Keywords:
Nervous system;
Sulphamethazine;
Perinatal period;
Neurotrophs
- From:
Journal of Environment and Health
1992;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of perinatal exposure to sulphamethazine on the expression of neurotrophs(NGF and BDNF) in the hippocampus of offspring in rats.Methods The dams(SD rats) were fed with sulphamethazine at the doses of 50,100 and 200 mg/(kg.d) respectively from gestational day 7 to postpartum day 21.The brains of the pups aged 30 days were collected and the expression of NGF and BDNF was determined by immunohistochemistry staining.Results The expression of NGF in CA1 and CA3 of hippocampus significantly decreased in all pups of perinatal exposure to sulfamethazine(P
