The molecular mechanism of lymphangiogenesis and lymphatic metastasis of malignant tumors
- VernacularTitle:淋巴管生成的分子机制与恶性肿瘤的淋巴转移
- Author:
Chao CHANG
;
Ping WANG
- Publication Type:Journal Article
- Keywords:
lymphatic metastasis;
malignant tumor;
vascular endothelial growth factor
- From:
China Oncology
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
The lymphatic vessel is one of the earliest routes for systemic neoplastic metastasis. But reports on research of the lymphatic vessel have been few compared to the study for tumor vessels. In the past few years,along with advances in understanding about the construction features of the lymphatic system,work has been done to determine the anatomic fundamentals of lymphatic metastasis. Many new specifi c markers of the lymphatic endothelium had been reported, which is useful to differentiate lymphatic vessels from capillary vessels. The lymphatic vessels are usually found in the animal tumor models, human tumors and peritumoral tissues. Furthermore, the molecular mechanism of lymph-angiogenesis has been discovered, which provide effective targets for anti-lymphatic metastasis of malignant tumors, make optimization of individualized treatment strategy possible to restrain lymph-angiogenesis of malignant tumors and so it could benefi t in improving patients' prognosis and survival.
