Effect of SU11248 on proliferation and apoptosis of myeloma cell line U266
- VernacularTitle:SU11248对骨髓瘤细胞U266增殖及凋亡作用的实验研究
- Author:
Donghong LIN
;
Lingqing LUO
;
Huiyu CHEN
;
Jianda HU
- Publication Type:Journal Article
- Keywords:
SU11248;
Multiple myeloma;
U266 cell;
Apoptosis
- From:
Chinese Journal of Immunology
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of SU11248 proliferation and apoptosis of multiple myeloma cell line U266 in vitro and analyze its mechanisms.Methods:Effect of SU11248 on proliferation of U266 cells was detected by MTT assay.The ability of SU11248 to induce apoptosis of U266 cells was examined by cell cycle analysis,TUNEL and DNA fragmentation.Expression of c-myc,hTERT,Bcl-2 and Bax mRNA in U266 cells was assessed by RT-PCR analysis.Results:The proliferation of U266 cells was inhibited by SU11248 in dose-and time-dependent manners (P
