Effects of Bile Acids on the Lipid Components in Human Erythrocyte Membranes
- VernacularTitle:胆汁酸对人红细胞膜脂质组分的影响及某些效应
- Author:
Weihua FENG
- Publication Type:Journal Article
- Keywords:
bile acid;
erythrocyte membrane;
phospholipid;
hemolysis
- From:
Academic Journal of Second Military Medical University
1981;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Fresh healthy human erythrocytes were treated by four kinds of bile acid solution (DOC, GDC, C-Na and GC-Na) at physiological and pathological concentrations of human serum level. The more hydrophobic bile acids (DOC and GDC) significantly affected lipid components of erythrocyte. membranes and morphology at concentration of 0.5 mmol/L and 1.0 mmol/L. To the extent of he-molysis DOC and GDC were more hemolytic than C-Na and GC-Na. Additionally the erthrocytes from patients with biliary obstruction were also studied. The results suggest that the more hydropho-bicity of bile acid, the more erythrocyte damage. The hydrophobicity was associated with the structure of bile acid molecules.
