Research Progress of Aplication of H295R Cell Line for Screening Environmental Steroid Hormone Disruptors
- VernacularTitle:H295R细胞系筛选环境类固醇激素干扰物的研究进展
- Author:
Jingming ZHOU
;
Jiqi LU
- Publication Type:Journal Article
- Keywords:
Environmental pollution;
Endocrine disruptor;
In vitro screening;
H295R cell line;
Adrenocortical steroid hormone disruptor
- From:
Journal of Environment and Health
1992;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
H295R cells can express all the key enzymes involved in the synthesis of steroid hormones,and have the ability to produce the steroid hormones found in the adult human adrenal cortex. Good correlation of response to toxicity has been reported between H295R cell line and normal adult human adrenal cells. H295R cell line can be used to evaluate effects of chemicals on gene expression,enzymatic activities and hormone production,and to explore the mode of action of chemicals on steroidgenesis. H295R cell line has been suggested as a potentially useful tool for screening environmental steroid hormone disruptors in vitro. The application of H295R cell line for screening environmental steroid hormone disruptors in vitro and its current issues are reviewed in this article.
