Etiology and pathogenesis of osteonecrosis of the femoral head
- VernacularTitle:股骨头坏死病因与发病机制研究进展
- Author:
Haiyan ZHAO
;
Yayi XIA
;
Pengde KANG
- Publication Type:Journal Article
- Keywords:
femoral head osteonecrosis;
etiology;
pathogenesis
- From:
Orthopedic Journal of China
2006;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Disruption of blood supply to the femoral head and subsequent hypoxia are implicated in the pathogenesis of osteonecrosis of the femoral head(ONFH),which frequently leads to the progressive collapse of the femoral head,thus causing degenerative arthritis of the hip joint.But the pathophysiology of osteonecrosis of the femoral head has not been completely elucidated.It is accepted that steroids and alcohol intake are two most common causes of ONFH.Now many theories have been proposed to decipher the etiology and pathogenesis of ONFH,including abnormal lipid metabolism,elevated intraosseous pressure,intravascular coagulation,second collision theory,etc.The purpose of this review is to summarize the etiology and pathogenesis of osteonecrosis of the femoral head.
