Hydroxycamptothecine plus oxaliplatin compared with fluorouracil/leucovorin (LV5FU2) plus oxaliplatin in the treatment of metastatic colorectal cancer:a randomized clinical study
- VernacularTitle:奥沙利铂联合羟基喜树碱与氟尿嘧啶治疗转移性结直肠癌的随机对照临床研究
- Author:
Sihai NING
;
Shaojun CHEN
;
Haixin HUANG
;
Guisheng LI
- Publication Type:Journal Article
- Keywords:
hydroxycamptothecine;
oxaliplatin;
fluorouracil/leucovorin;
metastatic colorectal cancer;
combined chemotherapy
- From:
China Oncology
1998;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
0.05).The median time to progression (mTTP) was 7.8 months in HCPTOX group and 7.9 months in FOLFOX4 group, respectively. The median survival time (MST) was 13.1 months in HCPTOX group and 13.3 months in FOLFOX4 group, respectively. The toxicities were well tolerated.The incidence of grade Ⅲ+Ⅳ nausea and vomiting was significantly lower in HCPTOX group than in FOLFOX4 group (?2=4.538,P0.05). Conclusion:Both of the two regimens were feasible, well tolerated and effective in treatment of metastatic colorectal cancer.HCPTOX regimen might be safer than FOLFOX4 regimen,especially in elderly patients or patients with ECOG PS of 1 to 2.
