Advances on LKB1 in the study of lung cancer
- VernacularTitle:抑癌基因LKB1在肺癌研究中的进展
- Author:
Junhua ZHANG
;
Haiquan CHEN
- Publication Type:Journal Article
- Keywords:
lung cancer;
LKB1;
tumor suppressor gene;
abnormal expression
- From:China Oncology
1998;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Recent studies have shown that the loss-of-function LKB1 mutations occur in approximately 30% of human non-small cell lung cancer(NSCLC). Studies from lung cancer animal models have demonstrated that functional loss of LKB1 dramatically promotes lung cancer invasion and progression, underscoring the essential role of LKB1 as a potent tumor suppressor involved in lung cancerigenesis, differentiation and metastasis. However, the relationship between loss-of-function LKB1 mutations and lung cancer prognosis remain largely unclear, therefore, we summarized the progress of the research on LKB1.
