Protective effect of reduced glutathione on renal mitochondria in rats with obstructive jaundice
- VernacularTitle:还原型谷胱甘肽对梗阻性黄疸大鼠肾脏线粒体保护作用的研究
- Author:
Zhiqiang CHEN
;
Yunzhi FANG
;
Tao LI
- Publication Type:Journal Article
- Keywords:
Jaundice, obstructive?Kedney failure?Mitochondria?Oxygen free radicals?Glutathione
- From:
Chinese Journal of Current Advances in General Surgery
1999;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the role of oxygen free radicals in renal dysfunction of rats with obstructive jaundice and the protective effect of reduced glutathione on renal mitochondria. Methods: Fifty-four Wistar rats were randomly divided into three groups: sham-operation control group (group A), obstructive jaundice group (group B), reduced glutathione treated group (group C). The model of obstructive jaundice in rats was established by common bile duct ligation (CBDL). In group C, reduced glutathione (150mg/kg.d) was given through abdominal cavity for 21 days. The rats were executed at 7th, 14th, and 21st day after operation respectively. The contents of serum BIL, Cr, BUN and the contents of renal mitochondria MDA and cholesterol were detected respectively, and the changes of renal histopathology were observed. Results: The contents of renal mitochondria MDA and cholesterol in group B and group C were markedly higher than group A (P
