Expressions of P27 protein and PCNA in oral squamous cell carcinomas
- VernacularTitle:口腔鳞状细胞癌中P27和增殖细胞核抗原的表达
- Author:
Xue WANG
;
Ruhui ZHANG
- Publication Type:Journal Article
- Keywords:
P27 protein;
PCNA;
OSCC;
Immunohistochemistry
- From:
Journal of Practical Stomatology
1996;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expressions of P27 protein and proliferating cell nuclear antigen(PCNA) in oral squamous cell carcinoma(OSCC) and to determine the relationship between them. Methods: SP immunohistochemistry was used to detect P27 protein and PCNA in 55 cases of OSCC, 5 biopsies of normal oral mucosa and 20 hyperplastic tissues. Results: The expression rate of P27 protein and PCNA in OSCC were 40.0%,80.0%,which were different from normal oral mucosa and hyperplasia tissues(P0.05). They correlated with malignant behaviors, clinical stages and whether there was lymphnode metastasis or not of the neoplasm(P0.05). Conclusion: Decrease of P27 protein expression and increase of PCNA expression may be important indicators which stand for malignant behavior of neoplasm. The results suggest that their inverse correlation between PCNA and P27 in various forms of oral squamous cell carcinomas may be of prognostic and therapy value.
