Comparison of two kinds of models of immune thrombocytopenic purpura in mice
- VernacularTitle:两种不同的免疫性血小板减少性紫癜小鼠模型的比较
- Author:
Hong WEI
;
Daquan LI
;
Runlin MA
- Publication Type:Journal Article
- Keywords:
Immune(Idiopathic) thrombocytopenic purpura;
Murine model;
Autoimmune disease
- From:
Chinese Journal of Immunology
1985;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze two different kinds of mouse model with immune thrombocytopenic purpura for the immune mechanisms.Methods:Immune thrombocytopenic purpura was induced by either injection of polyclonal antibody or immunized inoculation with rat platelets.Results:The two kinds of model all induced decrease of platelets,while immunization with platelets of rat induced alloantibodies in the mice.Conclusion:Immunization with platelets of rat can mimic the production process of autoantibodies in human and lead to immune thrombocytopenic purpura in mice.
