Organs Damage Caused by Di-(2-ethylhexyl) phthalate in Rats
- VernacularTitle:邻苯二甲酸二(2-乙基己基)酯对大鼠不同脏器的损伤
- Author:
Xiaoqin ZHONG
;
Hongping CAI
;
Hongping WAN
- Publication Type:Journal Article
- Keywords:
di-(2-ethylhexyl) phthalate(DEHP);
Rat;
Organ coeffcient;
Pathology
- From:
Journal of Environment and Health
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of di-(2-ethylhexyl) phthalate(DEHP) on the organs of rats.Methods Male Wister rats were divided into five groups,four exposure groups and one control group,10 in each.The exposure groups were given with DEHP at the doses of 1 500 mg /kg,3 000 mg /kg,4 500 mg /kg,6 000 mg /kg respectively,by gavage,28 consecutive days.The rats were weighed every 4 days,after 28 days,the rats were killed and the organ coefficients were calculated and the pathological examination was done.Results The weight of four exposure groups reduced significantly(P
