Oxidative Damage in Cultured CHL Cells Induced by Joint Action of Benzene and Formaldehyde
- VernacularTitle:苯和甲醛致细胞氧化损伤的联合作用初步探讨
- Author:
Chaoyan OU
;
Lu KONG
;
Jinshun ZHAO
- Publication Type:Journal Article
- Keywords:
Benzene;
Formaldehyde;
Joint action;
Oxidative damage
- From:
Journal of Environment and Health
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the joint action of benzene and formaldehyde for oxidative damage effects on cultured CHL cells.Methods Twenty-four hours after the cultured CHL cells exposed to formaldehyde(0,0,0,0.319 75,0.319 75,0.319 75,0.639 5,0.639 5,0.639 5 ?g/ml) or(and) benzene(0,0.392,0.784,0,0.392,0.784,0,0.392,0.784 mg/ml),the level of glutathione(GSH),malondialdehyde(MDA) and the activity of superoxide dismutase(SOD) were determined.Results Twenty-four hours after formaldehyde or(and) benzene exposure,the level of GSH reduced,activity of SOD reduced significantly(P
