Toxicokinetics Study of Lead Acetate in Domestic Rabbits
- VernacularTitle:醋酸铅在家兔体内的代谢动力学研究
- Author:
Na QI
;
Guang LIU
;
Yingmin ZHOU
- Publication Type:Journal Article
- Keywords:
Metal,heavy;
Lead acetate;
Domestic rabbit;
Toxicokinetics;
Differential potentiometric stripping analysis
- From:
Journal of Environment and Health
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To research the toxicokinetics model of lead acetate in the domestic rabbits.Methods Injecting lead acetate into the vein of the domestic rabbit at the dose of 3 mg/kg,then the blood was collected at the 10th,20th,30th,60th,90th,120th,180th,240th and 360th min.The concentrations of the blood lead were measured by differential potentiometric stripping analysis,the data were analyzed by DAS2.0 software.Results The linear was at the range of 10 to 50 ?g/ml,the major toxicokinetics parameters were:t1/2? = 8.60 min,t1/2? = 67.69 min,t1/2? = 729.84 min,V1= 77 033.08 L/kg,CL = 709.27 L/(min?kg),AUC(0-t) = 3 106.59 ng/(L?min).According to the smallest principle of AIC,the lead concentration in vivo conformed to the three compartmental models in domestic rabbit after injecting lead acetate at 3 mg/kg.Conclusion The lead concentration conforms to the three compartmental models in the domestic rabbit after intravascular injection of lead acetate,and it is eliminated according to the first order processes.
