The research on expression and clinical significance of MCM2 in BTCC
- VernacularTitle:微型染色体维持蛋白2在膀胱移行细胞癌中的表达及临床意义
- Author:
Aili ZHANG
;
Shubing HE
;
Zhihong ZHAO
;
Xiaochen NI
- Publication Type:Journal Article
- Keywords:
bladder neoplasms;
carcinoma,transitional cell;
MCM2;
Ki-67;
immunohistochemistry
- From:
China Oncology
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Background and purpose:It is verifi ed that MCM2 is a specifi c marker in the cell cycle,and expressed in all cells entering into the cycle,however,no expression is found in the differentiated cells and static period cell.Therefore,in the abnormally proliferative developmental cells and mutagenic cells,MCM2 could be used to mark the status of the cells as a cellular proliferative marker,and then to be a diagnostic tool for some heterotypical pathological changes and tumors.Our study demonstrated that the expression and clinical significance of MCM2 in bladder transitional cell cancer(BTCC).Methods:The expression of MCM2 was examined by immunohistochemistry Streptavidin-Peroxidase method in 12 cases of normal bladder tissues and 42 cases of BTCC.Results:The positive expression of MCM2 in BTCC was 100%,whereas in normal tissues,no positive expression was found(P0.05).The expression of MCM2 was closely associated with tumor pathological grade(P
