Expression of cyclooxysenase-2 in lymph node negative breast cancer lead to perfect the simple prognostic model
- VernacularTitle:环氧合酶-2表达与简易淋巴结阴性乳腺癌预后模型的补充
- Author:
Fangming LI
;
Zhimin SHAO
- Publication Type:Journal Article
- Keywords:
cyclooxysenase-2;
breast cancer;
prognosis
- From:China Oncology
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Background and purpose:Cyclooxysenase-2(COX-2)was first researched in colon caner,and extensively studied in breast cancer.However it was rarely reported in lymph node negative breast cancer.This study assessed the effect of expression of COX-2 in the prognosis of lymph node negative breast cancer and its use as information of COX-2 status to perfect the prognostic mathematic model.Methods:The expression of COX-2 protein was detected by IHC in 119 cases of lymph node negative breast cancer,the survival data was analyzed.Results:Elevated expression of COX-2 was associated with unfavorable distant disease-free survival(74% vs 93.86%).In subgroups by the simple prognostic model PI=size+HER2-2.5?age-CT-0.55?(ER?ET),the 5-year DFS were decreased with subgroups of low-risk,mid-risk and high-risk and the rate of elevated expression of COX-2 was increased with higher risk subgroups.Furthermore,in mid-risk group,the elevated expression of COX-2 was still able to predict poorer prognosis.Conclusion:The information of expression of COX-2 can be used to perfect the simple prognostic mathematic model,thus it would be more effective for treatment of breast cancer with auxiliary lymph nodes metastases.
