Patency rate and endothelialization study of displace of blood vessel with prostheses seeded by CD34~+ stem cells
- VernacularTitle:骨髓CD34~+干细胞种植人工血管应用于血管置换后内皮化和通畅率的研究
- Author:
Weishuai LIAN
;
Zhenhai YU
;
Kun WANG
;
Shuguang ZHANG
- Publication Type:Journal Article
- Keywords:
Blood vessel prosthesis?Antigens,CD34?Bone marrow transplantation
- From:
Chinese Journal of Current Advances in General Surgery
1999;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the endothelialization and intermediate and long-term patency rate of prostheses seeded by CD34+ stem cells.Methods:sixteen crossbred dogs were randomized into 2 groups.Prostheses covered with ePTFE or Dacron were implanted into the abdominal aorta artery(AAA) and inferior vena cava(IVC).Twelve dogs were implanted by prostheses seeded by CD34+ stem cells,4 dogs were implanted by autogenous blood only as control.The prostheses were explanted at thirty or sixty or one hundred days.Light and electron microscopy were applied to examine endothelialization of prostheses.CD34 factor stain was used to identify endothelial cells.Results:All venous prostheses implanted by autogenous blood were blocked.Others were patent.Confluent endothelial cells appeared on the neointima of seeded prostheses.There were no endothelial cells in the no-implanted prostheses.Conclusion:Endothelialization and higher patency rate might be achieved in the prostheses covered with ePTFE or Dacron that were implanted by CD34+ stem cells.
