Comparative in vivo biodistributions of nanoparticles and polymers of ¹⁷⁷lutetium-labeled hyaluronic acids in mice during 28 days.
10.14405/kjvr.2017.57.2.105
- Author:
Chunmei LIN
1
;
Ju Yeon JEONG
;
Jung Min YON
;
Seul Gi PARK
;
Lee Wha GWON
;
Jong Geol LEE
;
In Jeoung BAEK
;
Sang Soep NAHM
;
Beom Jun LEE
;
Young Won YUN
;
Sang Yoon NAM
Author Information
1. College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.
- Publication Type:Original Article
- Keywords:
drug delivery system;
hyaluronic acid;
in vivo biodistribution;
nanoparticle;
¹⁷⁷lutetium
- MeSH:
Animals;
Drug Delivery Systems;
Heart;
Humans;
Hyaluronic Acid*;
Kidney;
Liver;
Lung;
Male;
Mice*;
Mice, Inbred ICR;
Nanoparticles*;
Polymers*;
Radioactivity;
Spleen
- From:Korean Journal of Veterinary Research
2017;57(2):105-111
- CountryRepublic of Korea
- Language:English
-
Abstract:
Hyaluronic acid (HA) has been investigated for biomedical and pharmaceutical applications. This study was conducted to determine the distributions of HA nanoparticles (NPs; size 350–400 nm) and larger HA polymers in mice at intervals after application. ¹⁷⁷Lutetium (Lu)-labeled HA-NPs or HA polymers were intravenously injected (5 mg/kg) into male ICR mice, and radioactivity levels in blood and target organs were measured from 0.25 h to 28 days post-injection. In blood, the radioactivities of HA-NPs and HA polymer peaked at 0.5 h after injection but were remarkably decreased at 2 h; subsequently, they maintained a constant level until 6 days post-injection. HA-NPs and HA polymers were observed in the liver, spleen, lung, kidney, and heart (in ascending order) but were seldom observed in other organs. After 3 days, both the HA-NP and HA polymer levels showed similar steady decreases in lung, kidney, and heart. However, in liver and spleen, the HA-NP levels tended to decrease gradually after 1 day and both were very low after 14 days, whereas the HA polymer level accumulated for 28 days. The results indicate that HA-NPs, with their faster clearance pattern, may act as a better drug delivery system than HA polymers, especially in the liver and spleen.
