Effect of electroacupuncture on learning and memory in diabetic rats and the expression of connective tissue growth factor in hippocampus
- VernacularTitle:电针对糖尿病大鼠学习记忆及海马结缔组织生长因子表达的影响
- Author:
Ping MA
;
Zhong JI
;
Hang YU
;
Yurong CHU
- Publication Type:Journal Article
- Keywords:
electroacupuncture;
blood glucose;
learning and memory;
hippocampus;
connective tissue growth factor(CTGF)
- From:Journal of Xi'an Jiaotong University(Medical Sciences)
1982;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of electroacupuncture on improvement of learning and memory ability and the expression of connective tissue growth factor(CTGF)mRNA and protein in hippocampus in diabetic rats with cognitive impairment.Methods The rat diabetes model was induced by injecting streptozotocin(20 g/L),and then the rats were randomly divided into three groups:electro-acupuncture group(EA),diabetes-mellitus-untreated group(DM)and control group(CN).After four weeks of electroacupuncture treatment,blood glucose level was determined and the effect of electroacupuncture on learning and memory was examined with the device of Morris water maze.RT-PCR was used to detect CTGF mRNA level,and immunohistochemistry was used to detect CTGF protein expression.Results Blood glucose level and the latency period in DM group were increased compared with those in EA and CN groups(P
