Effect of Intestinal Function-recovering Decoction on the bacterial and endotoxin translocation as well as MDA and SOD in serum of rats with multiple organ dysfunction syndrome
- VernacularTitle:肠功能恢复汤对MODS大鼠细菌和内毒素移位及血清MDA和SOD含量的影响
- Author:
Chunrong WANG
;
Yonggang CHENG
;
Jin ZENG
- Publication Type:Journal Article
- Keywords:
Intestinal Function-recovering Decoction;
multiple organ dysfunction syndrome(MODS);
bacteria and endotoxin translocation;
malondialdehyde(MDA);
superoxide dismutase(SOD)
- From:Journal of Xi'an Jiaotong University(Medical Sciences)
1982;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of Intestinal Function-recovering Decoction on the bacteria and endotoxin translocation and the content of malondialdehyde(MDA)and superoxide dismutase(SOD)in serum of rats with multiple organ dysfunction syndrome(MODS).Methods Fifty-seven SD rats were divided into four groups randomly:control group,MODS group,decoction group and ampicillin group.We detected the content of endotoxin in the peripheral vein,portal vein and ileum.Bacterial translocation,change of ileum mucous membrane in pathomorphology and the contents of MDA,SOD,ALT,AST,Cr and BUN in serum in each group were also examined.Results The hepatic and renal function and ileum mucous membranes were significantly damaged in MODS group,decoction group and ampicillin group.Compared with those in MODS group,serum MDA,ALT,AST,Cr,BUN and endotoxin in the peripheral vein,portal vein and ileum in decoction group were significantly lower(P0.01).It exhibited a negative correlation between serum MDA and SOD in MODS group and ampicillin group(P
