Expression of IL-23 receptor on peripheral blood lymphocyte in patients with inflammatory bowel disease and its significance
- VernacularTitle:IL-23受体在炎症性肠病患者外周血淋巴细胞中的表达及意义
- Author:
Baisui FENG
;
Jie LUO
;
Zhanju LIU
- Publication Type:Journal Article
- Keywords:
interleukin-23 receptor;
inflammatory bowel disease;
T lymphocyte;
NK cell;
ulcerative colitis;
Crohn's disease
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
1982;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the expression of IL-23 receptor in T lymphocytes and NK cells in peripheral blood mononuclears(PBMC)from patients with inflammatory bowel disease(IBD)as well as its significance in the pathogenesis.Methods PBMC,isolated from 30 patients with UC,16 patients with CD and 30 healthy controls,were used to determine the expression of IL-23 receptor in T lymphocytes and NK cells by flow cytometry.The surface of lymphocytes was determined by three-colour flow cytometry in inflammatory bowel disease patients,and the results were compared with those of normal peripheral blood.Results The expression of IL-23R on peripheral CD4+ T,CD8+ T and CD56+ NK cells of patients was obviously higher than that in the control group.Conclusion The expression of IL-23R on T lymphocytes and NK cells of patients with IBD was increased,suggesting that IL-23 receptor plays an important role in the pathogenesis of IBD.
