Study on the expression of lymphotoxin-? in SLE and the clinical correlation
- VernacularTitle:SLE中淋巴毒素?基因表达及相关性研究
- Author:
Min SUN
- Publication Type:Journal Article
- Keywords:
Systemaic lupus erythematosis;
Lymphotoxin-?(LT-?);
Gene
- From:
Chinese Journal of Immunology
1985;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study expression of lymphotoxin-?(LT-?)in SLE patients with the relationship of inordinate immunoregulation.Methods:The 82 SLE patients and 90 normal controls'serum concentration of LT-? protein was detected with ELISA and PBLs were separated for analyses of its encoding sequence with RNA spot hybridization.The polymorphisms of LT-? gene in PBLs were analyzed by PCR-RFLP.Results:The expressing level of LT-? in SLE patients was significantly higher than in controls for both seral protein and mRNA inPBLs(P
