Study on natural killer cell receptor NKG2D and its ligand MICA/B in patients with leukemia
- VernacularTitle:白血病患者NK细胞表面NKG2D受体及其配体MICA/B的研究
- Author:
Xin CHANG
;
Li MA
;
Xiaojing ZENG
;
Hong LI
- Publication Type:Journal Article
- Keywords:
Leukemia;
NK cells;
NKG2D;
MICA/B
- From:
Chinese Journal of Immunology
1985;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression of NKG2D receptor on natural killer(NK)cells and the expression of its ligand MHC classⅠ-related chain A and B(MICA/B)whereby to analyze the mechanism for escaping killing were deteced by NK cells of leukemic cells.Methods:Detection of NKG2D receptor and MICA/B ligand were aleteced by flow cytometry analysis.Results:The expression of NKG2D receptor were significantly lower in both pretherapy and complete remission group,compared with that in health group(P0.05).Conclusion:NK cell function mediated by NKG2D-MICA/B was inhibited,with possibly leads to the escape of leukemic cell from NK cell cytotoxicity;And after therapy the function of NK cells mediated by MICA/B in complete remission patients may be not ameliorated indicated by farther decrease of NKG2D-cells in the patients.
