Evaluation of EMMPRIN(CD147) expression in cervical cancer:a critical role in development and progression
- VernacularTitle:细胞外基质金属蛋白酶诱导因子与宫颈癌发生发展的关系
- Author:
Xingzhu JU
;
Xiaoyan ZHOU
;
Ziting LI
;
Xiaohua WU
- Publication Type:Journal Article
- Keywords:
cervical cancer;
extracellular matrix metalloproteinase inducer;
metastasis
- From:China Oncology
2001;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
chronic cervicitis(0%),(P=0.000).The positive rates of EPMMPRIN overexpression in metastatic lymph nodes was 54.5%(12/22),no difference was found from corresponding primary tumor(72.7%,P=0.210).But EMMPRIN overexpression in primary tumor was related to lymph node metastasis(P=0.026),no relationship was found between EMMPRIN expression and other clinical-pathological parameters.Univariate analyses revealed that EMMPRIN expression did not correlate to tumor-specific survival.In contrast,lymph vascular space invasion,deep stromal invasion and lymph node metastasis were significantlyassociated with poor prognosis.In multivariate analysis,lymph-node metastasis was the independent prognostic factor for tumor-specific survival(P=0.006;HR=0.038;95% confidence interval,0.0190.763).Conclusion:EMMPRIN overexpression may play an important role in progression of human cervical cancer,and in the development of cervical cancer from CIN.
