Relation between prognosis and expression of MTA1 in patients with osteosarcoma after chemotherapy
- VernacularTitle:MTA1在化疗后骨肉瘤中的表达及其与预后的关系
- Author:
Guoqiang BU
;
Xiuchun YU
- Publication Type:Journal Article
- Keywords:
osteosarcoma;
neoadjuvant chemotherapy;
MTA1;
prognosis
- From:
Orthopedic Journal of China
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
[Objective]To discuss the clinical and the biological significance of the expression of residual tumor cells MTA1 in the occurrence and progression of osteosarcoma after chemotherapy,and to investigate the correlation between MTA1 expression and the prognosis in osteosarcoma patients.[Method]SP immunohistochemical technique was used to detect the expression of MTA1 in the residual tumor cells from 31 osteosarcoma patients after chemotherapy.[Result]Among 17 patients with positive MTA1 expression,6 had good prognosis(35.29%);and among 14 patients with negative MTA1 expression,11 had good prognosis(78.57%).There were significant differences between groups(P
