Investigation on the effects of CD44 in lung tissue in allergy-induced rat asthmatic model
- VernacularTitle:粘附分子CD44在支气管哮喘发病中的实验研究
- Author:
Ling LI
;
Li YANG
;
Heng TANG
;
Rui JIN
- Publication Type:Journal Article
- Keywords:
Asthma;
CD44;
Cell adhesion molecule
- From:
Chinese Journal of Immunology
1985;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the expression of cell adhesion molecule CD44 in lung tissue of rats with asthma.Methods:32 SD rats were randomly divided into 4 groups:the normal group and the model group,8 rats in each group.The asthmatic model was established by repeated inhalation of ovalbulium.The expression of CD44 in lung tissue of rats was detected by semi-quantitatively reverse transcription-polymerase chain reaction(RT-PCR) and by means of immuno-histochemical staining.Differential leukocytes counts(neutrophils,eosinophils,and lymphocytes) in bronchoalveolar lavage fluid(BALF) were performed after staining with wright staining.Results:The expressions of CD44 increased one week after OVA challenge(P
