Effects of idazoxan on changes of neuroglia in spinal cords of rats with experimental autoimmune encephalomyelitis
- VernacularTitle:咪唑克生对实验性自身免疫性脑脊髓炎大鼠脊髓内胶质细胞变化的影响
- Author:
Zhenguo ZHU
;
Rongyuan ZHENG
;
Jianmin LI
;
Zhao HAN
;
Xinshi WANG
- Publication Type:Journal Article
- Keywords:
Idazoxan;
Experimental autoimmune encephalomyelitis;
Astroglia;
Microglia
- From:
Chinese Journal of Immunology
1985;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore effects of Idazoxan(IDA) on changes of neuroglial cells in spinal cords of rats with experimental autoimmune encephalomyelitis(EAE).Methods:Rat EAE was induced by immunization with spinal cord homogenates of Geania pigs.EAE clinical manifestations were assessed in terms of the scoring standards.Histological investigation and immunohistochemistry were observed for the inflammatory dedmylinative lesion of CNS and morphology of glial cells.Results:Ida could not decrease the incidence of EAE,but alleviate its clinical manifestation and histological changes.On day 15 after immunization,astrocytes in and around the inflammatory dedmylinative lesion of CNS in EAE rats treated with Ida increased in number and size,on the contrary,microglia decreased in number and size.Conclusion:Ida has protective effects on EAE and its functional mechanism may be concerned with modulation of immunological mechanism of CNS.
