Animal experimental study of fracture fixation with PDLLA mixed with chitosan
- VernacularTitle:消旋聚乳酸混合壳聚糖短状骨髓内钉固定骨折的动物实验研究
- Author:
Chaotong HUANG
;
Jingkuang LI
;
Jiakai ZHU
- Publication Type:Journal Article
- Keywords:
absorbable material;
intramedullary nails;
fracture
- From:
Orthopedic Journal of China
2006;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
[Objective]To explore the effect of fracture healing with intramedullary nail of poly-DL-lactic acid(PDLLA) mixed with chitosan and basic fibroblast growth factor(b-FGF),and provides the basis for clinical application.[Method]Middle tibia fracture model of 120 healthy adult rabbits of New Zealand were established and randomly divided into 6 groups as follows:experimental(A):30 rabbits with PDLLA+CHS+ b-FGF;control:5 groups(18 animals for each group):control(B) with PDLLA+CHS,control(C) with PDLLA,control(D) with PDLLA+b-FGF,control(E) with Kirschner's wire,and control(F) with Kirschner's wire+b-FGF.Radiological and histological follow-up was performed in 4,8,12 weeks postoperatively.[Result]All animals were survival.There was no significant difference(P
