Genetic Toxicity of Aluminium Trichloride in Male Mice
- VernacularTitle:三氯化铝暴露致雄性小鼠生殖细胞的遗传毒性
- Author:
Huihui CUI
;
Xiaoqin BAI
;
Li LI
- Publication Type:Journal Article
- Keywords:
Aluminium;
Testis;
Sperm;
Genetic toxicity
- From:
Journal of Environment and Health
1993;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the genetic toxicity of aluminium trichloride on reproductive cells of male mice.Methods Twenty healthy male KM mice were randomly divided into four groups,the experimental groups(50,75,100 mg/kg AlCl3 respectively) and the normal control group(0.9% NS),all of the groups were exposed by intraperitoneal injection,2 consecutive days with one day interval,for 2 weeks.The variation of body weight and index of testicle was observed,olive tail moment was evaluated by comet assay while sperm nucleus immaturity rate was examined by fluorescent staining sperm nucleus.Results Compared with the negative control group,the index of testicle in each AlCl3 treated group decreased significantly(P
