Expression of Stromal Cell-Derived Factor-1 and Its Clinical Significance in Blood Plasma of Patients with Breast Tumor
- VernacularTitle:基质细胞衍化因子-1在乳腺肿瘤患者血浆中的表达及其临床意义
- Author:
Jinbo TAO
;
Hua KANG
;
Tao HAI
;
Haichen SUN
;
Shuang LIU
- Publication Type:Journal Article
- Keywords:
Breast cancer Stromal cell-derived factor-1 Lymph node Metastasis
- From:
Chinese Journal of Bases and Clinics in General Surgery
2008;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of stromal cell-derived factor-1(SDF-1)and its clinical significance in blood plasma of patients with breast tumor.Methods The level of SDF-1 protein was examined by enzyme linked immunosorbent assay(ELISA)in blood plasma of 26 patients with breast benign tumor and 52 patients with breast cancer.Results The SDF-1 protein in blood plasma was detected in both breast benign tumor patients and breast cancer ones.The level of SDF-1 protein in patients with breast cancer was higher than that in ones with breast benign tumor,and there was a statistical difference between them(P=0.000).In patients with breast cancer,the level of SDF-1 protein in axillary lymph node(ALN)metastasis positive patients was significantly higher than that in ALN metastasis negative ones(P=0.036).Conclusion The level of SDF-1 protein in blood plasma may be a specific tumor marker.Its level is correlated with lymph node involvement in breast cancer.
